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Acetyl-l-carnitine is a first-in-class epigenetic regulator of genes involved in analgesic action such as the metabotropic glutamate 2 [mGlu2] receptor gene, neurotrophic factors, and antioxidant enzymes (e.g., superoxide dismutase) (Fig

Lee, E., Walker, C., & Ayadi, B

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this is consistent with the fact that previous large clinical trials have not reached a conclusion on whether cardiovascular disease can be suppressed by strict glycaemic control [6]

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